Across TCGA patient cohorts, HACD4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HACD4-associated genes across cancer lineages are GSK-3a-b_pS21_S9, ACVRL1, and JNK2. Each is linked with HACD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HACD4-to-partner and partner-to-HACD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HACD4→partner) and Y-score (partner→HACD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.471	+2.321	.028	.035	3	1
UCEC	ACVRL1 →	-0.175	-3.150	.010	.019	3	1
UCEC	JNK2 →	+0.197	+2.834	.048	.034	3	1
UCEC	Myosin-IIa_pS1943 →	+0.213	+2.335	.040	.020	3	1
UCEC	N-Ras →	-0.201	-3.446	<.001	.005	3	1
UCEC	p27_pT157 →	-0.066	-2.321	.023	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

HACD4 survival (RNA) · tumor vs normal (RNA) · all HACD4 data types