HACD3

Across TCGA pan-cancer cohorts, HACD3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HACD3 data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HACD3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HACD3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where HACD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.878	0.543	.018	8	view →
HNSC	DFS	Tertile	III,IV	0.409	0.852	.020	6	view →
LUAD	OS	Quartile	All	0.611	0.987	.026	3	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.529	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HACD3–CCRCC (DFS)

Open the CCRCC breakdown →