HACD3

Across TCGA patient cohorts, HACD3 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,162 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HACD3-associated proteins across cancer lineages are SMAD3, AAGAB, and HACD3_S114. Each is linked with HACD3 in more than 6 cancer types. Because this analysis shows association rather than direction, both HACD3-to-partner and partner-to-HACD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HACD3 versus SMAD3 in OV, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HACD3→partner) and Y-score (partner→HACD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMAD3 →	+0.559	+0.527	<.001	<.001	3	7
BRCA	AAGAB →	+0.393	+0.724	<.001	<.001	3	6
PDAC	HACD3_S114 →	+0.508	+0.257	<.001	<.001	3	6
LSCC	THEMIS2 →	-0.522	-0.736	<.001	<.001	3	6
BRCA	ZNF609_S758 →	+0.786	+0.828	<.001	<.001	3	5
LSCC	CACYBP →	+0.319	+0.518	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,162 associations by consensus.

HACD3 vs SMAD3 — OV

Explore this scatter interactively →