HACD3

Across TCGA patient cohorts, HACD3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HACD3-associated genes across cancer lineages are MEK1, MYH11, and PKC-a. Each is linked with HACD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HACD3-to-partner and partner-to-HACD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HACD3-low versus HACD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HACD3→partner) and Y-score (partner→HACD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.497	+3.459	.006	.005	3	1
UCEC	MYH11 →	+1.191	+2.321	.039	.035	3	1
UCEC	PKC-a →	+0.501	+2.820	.013	.035	3	1
UCEC	Tuberin →	+0.336	+3.459	.012	.005	3	1
UCEC	XBP1 →	-0.214	-3.000	.002	.036	3	1
UCEC	CD49b →	-0.340	-3.150	.017	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1 by HACD3 expression — UCEC

Explore this box plot interactively →