HACD3

Across TCGA cell cohorts, HACD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,592 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HACD3-associated GO terms across cancer lineages are Double-strand break repair via break-induced replication, DNA integrity checkpoint signaling, and DNA strand elongation involved in DNA replication. Each is linked with HACD3 in more than 13 cancer types. Because this analysis shows association rather than direction, both HACD3-to-partner and partner-to-HACD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via break-induced replication grouped by HACD3-low versus HACD3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HACD3→partner) and Y-score (partner→HACD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Double-strand break repair via break-induced replication →	+0.190	+0.544	.008	.002	3	14
BONE	DNA integrity checkpoint signaling →	+0.092	+0.667	.001	<.001	3	14
BONE	DNA strand elongation involved in DNA replication →	+0.185	+0.748	<.001	<.001	3	13
BONE	Double-strand break repair →	+0.088	+0.669	.004	.002	2	14
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle checkpoint →	+0.095	+1.035	<.001	<.001	3	13
BREAST	Defense response to bacterium →	-0.148	-1.150	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,592 associations by consensus.

Double-strand break repair via break-induced replication by HACD3 expression — BONE

Explore this box plot interactively →