HACD1

Across TCGA pan-cancer cohorts, HACD1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HACD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HACD1 RNA is repressed in tumor relative to normal tissue. In most cancer types HACD1 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and THCA are the cancer types where HACD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HACD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.055	<.001	12	view →
BLCA	Male	All	−2.183	<.001	11	view →
THCA	Male	All	+1.270	<.001	11	view →
KIRP	All	II,III,IV	+0.936	<.001	9	view →
LUAD	Female	II,III,IV	−1.640	<.001	8	view →
LUSC	Female	All	−1.493	<.001	8	view →
UCEC	All	All	−1.727	<.001	6	view →
KICH	Female	II,III,IV	−1.652	<.001	6	view →
STAD	All	All	−1.226	<.001	6	view →
BRCA	All	III,IV	−1.043	<.001	6	view →
HNSC	All	II,III,IV	+0.357	.014	3	view →
READ	Female	All	−2.538	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HACD1–KIRC

Open the KIRC breakdown →