HABP4

Across TCGA patient cohorts, HABP4 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HABP4-associated genes across cancer lineages are mTOR_pS2448, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with HABP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HABP4-to-partner and partner-to-HABP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by HABP4-low versus HABP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HABP4→partner) and Y-score (partner→HABP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.209	-3.886	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.497	-2.401	.006	.003	3	2
UCEC	PDCD4 →	-0.629	-3.459	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.265	-1.906	.008	.016	3	1
UCEC	A-Raf_pS299 →	-0.117	-2.459	.014	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.124	-2.415	.013	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

mTOR_pS2448 by HABP4 expression — UCEC

Explore this box plot interactively →