H6PD

Across TCGA pan-cancer cohorts, H6PD mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated H6PD data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher H6PD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated H6PD expression acts as an unfavorable survival marker.

COAD, CCRCC, and LSCC are the cancer types where H6PD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.825	1.000	.024	30	view →
CCRCC	OS	Median	III,IV	0.202	0.985	.007	16	view →
LSCC	DFS	Quartile	II,III,IV	0.433	0.861	.020	10	view →
PDAC	DFS	Median	III,IV	0.503	0.844	.013	7	view →
HNSC	OS	Tertile	II,III,IV	0.638	0.819	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

H6PD–COAD (DFS)

Open the COAD breakdown →