H6PD

Across TCGA patient cohorts, H6PD protein abundance is significantly associated with the RNA expression of many other genes, with 18,700 significant associations in total. GBM shows the largest number of these associations.

The most reproducible H6PD-associated genes across cancer lineages are SSPN, COL5A1, and HLX. Each is linked with H6PD in more than 5 cancer types. Because this analysis shows association rather than direction, both H6PD-to-partner and partner-to-H6PD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H6PD versus SSPN in HNSC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H6PD→partner) and Y-score (partner→H6PD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SSPN →	+0.903	+0.381	<.001	<.001	3	6
GBM	COL5A1 →	+1.691	+0.575	<.001	<.001	3	6
GBM	HLX →	+0.475	+0.528	<.001	<.001	3	6
GBM	CYP1B1 →	+1.040	+0.449	.003	<.001	3	6
BRCA	FBLN5 →	+1.224	+0.521	<.001	<.001	3	6
BRCA	COLEC12 →	+1.036	+0.364	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,700 associations by consensus.

H6PD vs SSPN — HNSC

Explore this scatter interactively →