H6PD

Across TCGA cell cohorts, H6PD RNA expression is significantly associated with the go_rna of many other GO terms, with 5,111 significant associations in total. CNS shows the largest number of these associations.

The most reproducible H6PD-associated GO terms across cancer lineages are Negative regulation of autophagy, Regulation of pattern recognition receptor signaling pathway, and Cytosolic transport. Each is linked with H6PD in more than 15 cancer types. Because this analysis shows association rather than direction, both H6PD-to-partner and partner-to-H6PD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by H6PD-low versus H6PD-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H6PD→partner) and Y-score (partner→H6PD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of autophagy →	+0.105	+1.167	<.001	.001	3	16
STOMACH	Regulation of pattern recognition receptor signaling pathway →	+0.056	+1.080	<.001	<.001	3	16
STOMACH	Cytosolic transport →	+0.092	+1.636	.001	<.001	3	14
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.159	+1.234	<.001	.001	3	14
STOMACH	Protein polyubiquitination →	+0.060	+1.178	<.001	<.001	3	14
CNS	Glycoprotein catabolic process →	+0.104	+0.942	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,111 associations by consensus.

Negative regulation of autophagy by H6PD expression — STOMACH

Explore this box plot interactively →