H6PD

Across TCGA cell cohorts, H6PD mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H6PD-associated genes across cancer lineages are AVP, SEC14L4, and SLC13A5. Each is linked with H6PD in more than 1 cancer types. Because this analysis shows association rather than direction, both H6PD-to-partner and partner-to-H6PD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by H6PD-low versus H6PD-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H6PD→partner) and Y-score (partner→H6PD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AVP →	+0.078	+4.392	<.001	.004	3	1
SOFT_TISSUE	SEC14L4 →	+0.521	+3.999	<.001	.004	3	1
SOFT_TISSUE	SLC13A5 →	+0.360	+3.700	.002	.008	2	2
SOFT_TISSUE	CCDC185 →	+0.038	+3.635	<.001	.007	3	1
SOFT_TISSUE	FTMT →	+0.052	+4.392	<.001	.004	3	1
SOFT_TISSUE	ZAR1 →	+0.082	+3.865	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

AVP by H6PD expression — SOFT_TISSUE

Explore this box plot interactively →