H4P1

Across TCGA pan-cancer cohorts, H4P1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of H4P1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where H4P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H4P1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

COAD, KICH, and BRCA are the cancer types where H4P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H4P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.082	.007	4	view →
KICH	Male	IV	+0.340	.001	2	view →
BRCA	Female	All	−0.070	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

H4P1–COAD

Open the COAD breakdown →