H4C8

Across TCGA pan-cancer cohorts, H4C8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated H4C8 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher H4C8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H4C8 expression acts as an unfavorable survival marker.

KIRC and DLBC are the cancer types where H4C8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.182	0.805	.003	15	view →
DLBC	OS	Median	All	0.053	0.936	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

H4C8–KIRC (OS)

Open the KIRC breakdown →