H4C7

Across TCGA pan-cancer cohorts, H4C7 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H4C7 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher H4C7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H4C7 expression acts as an unfavorable survival marker.

SKCM, OV, and UCEC are the cancer types where H4C7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.289	0.784	.001	26	view →
OV	DFS	Median	All	0.160	0.541	.003	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LGG	OS	Median	All	0.333	0.830	.012	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

H4C7–SKCM (OS)

Open the SKCM breakdown →