H4C7

Across TCGA patient cohorts, H4C7 mutation is significantly associated with the RNA expression of many other genes, with 163 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H4C7-associated genes across cancer lineages are MIR7843, IGHVII-33-1, and LINC01205. Each is linked with H4C7 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4C7-to-partner and partner-to-H4C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7843 grouped by H4C7-low versus H4C7-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C7→partner) and Y-score (partner→H4C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR7843 →	+0.459	+5.418	<.001	.005	3	2
LGG	IGHVII-33-1 →	+0.139	+7.977	<.001	.007	3	2
UCEC	LINC01205 →	+0.155	+4.102	<.001	<.001	3	2
UCEC	MYOM3-AS1 →	+0.100	+3.329	.005	.005	3	2
LIHC	LINC01707 →	+0.109	+5.355	.009	.005	3	2
LIHC	SERBP1P4 →	+0.111	+6.305	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 163 associations by consensus.

MIR7843 by H4C7 expression — CESC

Explore this box plot interactively →