H4C7

Across TCGA cell cohorts, H4C7 RNA expression is significantly associated with the mutation status of many other genes, with 36 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible H4C7-associated genes across cancer lineages are PRDM16, WDR64, and CARD8. Each is linked with H4C7 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4C7-to-partner and partner-to-H4C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDM16 grouped by H4C7-low versus H4C7-high in OESOPHAGUS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C7→partner) and Y-score (partner→H4C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRDM16 →	+4.906	+0.276	.006	<.001	3	2
BLOOD_Lymphoma	WDR64 →	+5.247	+0.142	.001	<.001	3	2
LUNG_NSCLC_LUSC	CARD8 →	+4.643	+0.389	.008	<.001	3	1
LUNG_NSCLC_LUSC	DHX34 →	+4.643	+0.389	.008	<.001	3	1
LUNG_NSCLC_LUSC	CAPN11 →	+4.643	+0.389	.008	<.001	3	1
LUNG_NSCLC_LUSC	FRMD4A →	+4.643	+0.389	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PRDM16 by H4C7 expression — OESOPHAGUS

Explore this box plot interactively →