H4C7

Across TCGA cell cohorts, H4C7 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H4C7-associated genes across cancer lineages are OR10AC1, ACSM4, and C20orf85. Each is linked with H4C7 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4C7-to-partner and partner-to-H4C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10AC1 grouped by H4C7-low versus H4C7-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C7→partner) and Y-score (partner→H4C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR10AC1 →	+0.080	+4.269	<.001	.005	3	1
LUNG_SCLC	ACSM4 →	+0.051	+4.044	<.001	.009	3	1
BLOOD_Leukemia	C20orf85 →	+0.049	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IL22 →	+0.050	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.234	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRT24 →	+0.096	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR10AC1 by H4C7 expression — LUNG_SCLC

Explore this box plot interactively →