H4C5

Across TCGA patient cohorts, H4C5 mutation is significantly associated with the RNA expression of many other genes, with 113 significant associations in total. CESC shows the largest number of these associations.

The most reproducible H4C5-associated genes across cancer lineages are MIR6876, KRTAP4-2, and RNU6-310P. Each is linked with H4C5 in more than 2 cancer types. Because this analysis shows association rather than direction, both H4C5-to-partner and partner-to-H4C5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6876 grouped by H4C5-low versus H4C5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C5→partner) and Y-score (partner→H4C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR6876 →	+0.414	+4.539	<.001	.008	3	3
CESC	KRTAP4-2 →	+0.067	+5.196	.001	.001	3	2
CESC	RNU6-310P →	+0.315	+4.969	<.001	.004	3	2
COAD	RNU2-8P →	+0.437	+7.741	<.001	.009	3	2
COAD	MTND3P16 →	+0.149	+7.741	<.001	.009	3	2
LUSC	RNU6-54P →	+0.194	+5.005	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

MIR6876 by H4C5 expression — CESC

Explore this box plot interactively →