H4C4

Across TCGA pan-cancer cohorts, H4C4 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated H4C4 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher H4C4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H4C4 expression acts as an unfavorable survival marker.

COAD and LIHC are the cancer types where H4C4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.205	0.809	<.001	24	view →
LIHC	OS	Median	All	0.198	0.777	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

H4C4–COAD (OS)

Open the COAD breakdown →