H4C4

Across TCGA patient cohorts, H4C4 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,815 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible H4C4-associated proteins across cancer lineages are VRK1, NASP, and RRM2. Each is linked with H4C4 in more than 5 cancer types. Because this analysis shows association rather than direction, both H4C4-to-partner and partner-to-H4C4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H4C4 versus VRK1 in GBM, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C4→partner) and Y-score (partner→H4C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VRK1 →	+0.440	+1.070	<.001	<.001	3	6
GBM	NASP →	+0.404	+0.839	<.001	<.001	3	6
UCEC	RRM2 →	+0.679	+1.204	.001	.006	3	6
LSCC	HAT1 →	+0.488	+0.917	.001	.003	3	6
HNSC	POLD3 →	+0.515	+1.911	<.001	<.001	3	6
GBM	TTK_S436 →	+0.955	+1.633	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,815 associations by consensus.

H4C4 vs VRK1 — GBM

Explore this scatter interactively →