H4C4

Across TCGA patient cohorts, H4C4 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible H4C4-associated genes across cancer lineages are Fibroblasts and Pericytes. Each is linked with H4C4 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4C4-to-partner and partner-to-H4C4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibroblasts grouped by H4C4-low versus H4C4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C4→partner) and Y-score (partner→H4C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Fibroblasts →	+0.020	+5.339	.001	.047	3	1
BLCA	Pericytes →	+0.107	+4.173	<.001	.027	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Fibroblasts by H4C4 expression — HNSC

Explore this box plot interactively →