H4C4

Across TCGA cell cohorts, H4C4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,060 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H4C4-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription, elongation, Extracellular matrix organization, and Positive regulation of stem cell population maintenance. Each is linked with H4C4 in more than 5 cancer types. Because this analysis shows association rather than direction, both H4C4-to-partner and partner-to-H4C4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription, elongation grouped by H4C4-low versus H4C4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C4→partner) and Y-score (partner→H4C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of DNA-templated transcription, elongation →	+0.072	+0.396	.001	.007	3	6
BLOOD_Leukemia	Extracellular matrix organization →	-0.033	-0.584	<.001	<.001	3	6
BONE	Positive regulation of stem cell population maintenance →	+0.043	+0.436	.002	.009	3	5
BONE	Regulation of leukocyte migration →	-0.113	-0.699	<.001	.001	3	5
BLOOD_Leukemia	Negative regulation of chondrocyte differentiation →	-0.142	-0.410	<.001	<.001	3	5
BONE	Extracellular structure organization →	-0.172	-0.580	.009	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,060 associations by consensus.

Negative regulation of DNA-templated transcription, elongation by H4C4 expression — SOFT_TISSUE

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