Across TCGA patient cohorts, H4C3 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible H4C3-associated genes across cancer lineages are RNU6-1127P, TRAJ53, and RPL17P19. Each is linked with H4C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4C3-to-partner and partner-to-H4C3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C3→partner) and Y-score (partner→H4C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1127P →	+0.401	+5.912	<.001	.002	3	2
HNSC	TRAJ53 →	+0.767	+5.736	<.001	.003	3	2
HNSC	RPL17P19 →	+0.083	+5.912	.005	.002	3	2
LUSC	MIR516A1 →	+1.541	+7.924	<.001	.008	3	2
HNSC	HNRNPRP2 →	+0.101	+5.182	<.001	.007	3	2
SKCM	SDAD1P3 →	+0.088	+4.884	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

Exploration

H4C3 survival (RNA) · tumor vs normal (RNA) · all H4C3 data types