Across TCGA patient cohorts, H4C3 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible H4C3-associated genes across cancer lineages are Astrocytes, Monocytes, and CD4+ memory T-cells. Each is linked with H4C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4C3-to-partner and partner-to-H4C3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C3→partner) and Y-score (partner→H4C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	Astrocytes →	+0.164	+5.479	<.001	.043	3	1
LIHC	Monocytes →	+0.014	+5.305	.007	.048	3	1
UCEC	CD4+ memory T-cells →	+0.041	+3.202	.008	.047	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

H4C3 survival (RNA) · tumor vs normal (RNA) · all H4C3 data types