Across TCGA cell cohorts, H4C3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,474 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible H4C3-associated GO terms across cancer lineages are CENP-A containing chromatin assembly, Meiotic sister chromatid cohesion, and Chromosome localization. Each is linked with H4C3 in more than 10 cancer types. Because this analysis shows association rather than direction, both H4C3-to-partner and partner-to-H4C3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C3→partner) and Y-score (partner→H4C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CENP-A containing chromatin assembly →	+0.178	+0.752	.005	<.001	3	11
LUNG_NSCLC_LUAD	Meiotic sister chromatid cohesion →	+0.117	+0.654	<.001	.001	3	11
SOFT_TISSUE	Chromosome localization →	+0.104	+0.730	<.001	<.001	3	11
SOFT_TISSUE	Positive regulation of G2/MI transition of meiotic cell cycle →	+0.108	+0.424	.001	.003	3	11
PANCREAS	DNA replication initiation →	+0.155	+0.702	.002	<.001	3	10
STOMACH	Meiotic chromosome segregation →	+0.135	+0.614	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,474 associations by consensus.

Exploration

H4C3 survival (RNA) · tumor vs normal (RNA) · all H4C3 data types