Across TCGA cell cohorts, H4C3 protein abundance is significantly associated with the RNA expression of many other genes, with 3,570 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H4C3-associated genes across cancer lineages are SP4, RAB15, and PHLDB2. Each is linked with H4C3 in more than 5 cancer types. Because this analysis shows association rather than direction, both H4C3-to-partner and partner-to-H4C3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C3→partner) and Y-score (partner→H4C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SP4 →	+1.354	+1.459	.001	.003	3	6
LUNG_SCLC	RAB15 →	+1.331	+0.841	.001	<.001	3	6
BONE	PHLDB2 →	+2.687	+1.042	<.001	.003	3	5
BLOOD_Myeloma	BRICD5 →	+1.887	+0.716	<.001	<.001	3	5
LUNG_SCLC	ZFHX3 →	+0.889	+0.760	<.001	<.001	3	5
LUNG_SCLC	WEE1 →	+0.795	+0.561	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,570 associations by consensus.

Exploration

H4C3 survival (RNA) · tumor vs normal (RNA) · all H4C3 data types