H4C2

Across TCGA pan-cancer cohorts, H4C2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated H4C2 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher H4C2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H4C2 expression acts as an unfavorable survival marker.

CESC, COAD, and ACC are the cancer types where H4C2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.103	0.588	.015	18	view →
COAD	DFS	Median	All	0.164	0.783	<.001	14	view →
ACC	DFS	Median	All	0.068	0.667	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

H4C2–CESC (OS)

Open the CESC breakdown →