H4C2

Across TCGA patient cohorts, H4C2 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H4C2-associated genes across cancer lineages are RBMY1HP, USP17L16P, and RNU6-706P. Each is linked with H4C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4C2-to-partner and partner-to-H4C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1HP grouped by H4C2-low versus H4C2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C2→partner) and Y-score (partner→H4C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RBMY1HP →	+0.024	+7.954	<.001	.008	3	1
HNSC	USP17L16P →	+0.029	+7.954	<.001	.008	3	1
HNSC	RNU6-706P →	+0.263	+7.954	<.001	.008	3	1
HNSC	CT45A9 →	+0.044	+7.954	<.001	.008	3	1
CESC	OR5D3P →	+0.048	+6.837	<.001	<.001	3	1
CESC	RNA5SP453 →	+0.370	+5.306	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

RBMY1HP by H4C2 expression — HNSC

Explore this box plot interactively →