H4C14

Across TCGA pan-cancer cohorts, H4C14 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated H4C14 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher H4C14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H4C14 expression acts as an unfavorable survival marker, although some lineages such as OV and UCEC show a favorable association.

UCS, ACC, and LGG are the cancer types where H4C14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	III,IV	0.185	0.538	<.001	78	view →
ACC	DFS	Median	All	0.195	0.653	<.001	49	view →
LGG	OS	Median	All	0.364	0.551	<.001	49	view →
HNSC	DFS	Median	II,III,IV	0.289	0.425	.005	40	view →
UVM	OS	Quartile	All	0.440	0.773	.016	38	view →
ESCA	DFS	Median	All	0.280	0.432	.006	34	view →
COAD	OS	Tertile	All	0.395	0.657	.003	27	view →
PAAD	DFS	Quartile	All	0.222	0.555	.003	25	view →
OV	DFS	Tertile	IV	0.575	0.277	.002	24	view →
GBM	OS	Median	All	0.269	0.547	<.001	22	view →
BLCA	DFS	Median	II,III,IV	0.283	0.397	.018	19	view →
MESO	DFS	Median	III,IV	0.140	0.686	<.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

H4C14–UCS (DFS)

Open the UCS breakdown →