H4C13

Across TCGA pan-cancer cohorts, H4C13 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated H4C13 data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher H4C13 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H4C13 expression acts as an unfavorable survival marker, although some lineages such as STAD and BLCA show a favorable association.

ACC, LIHC, and ESCA are the cancer types where H4C13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.114	0.892	<.001	72	view →
LIHC	DFS	Tertile	III,IV	0.128	0.364	.001	54	view →
ESCA	DFS	Quartile	II,III,IV	0.365	0.667	.002	50	view →
STAD	OS	Tertile	III,IV	0.576	0.239	.008	50	view →
LGG	OS	Tertile	All	0.177	0.454	<.001	33	view →
BLCA	OS	Quartile	III,IV	0.634	0.322	.001	26	view →
MESO	OS	Tertile	All	0.392	0.582	.029	18	view →
DLBC	DFS	Median	All	0.947	0.577	.010	16	view →
THYM	OS	Median	All	0.956	0.593	.007	15	view →
UCS	OS	Median	All	0.790	0.565	.014	14	view →
SARC	OS	Quartile	All	0.759	0.845	.022	13	view →
THCA	OS	Tertile	IV	0.720	1.000	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

H4C13–ACC (OS)

Open the ACC breakdown →