H3Y2

Across TCGA patient cohorts, H3Y2 protein abundance is significantly associated with the RNA expression of many other genes, with 858 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible H3Y2-associated genes across cancer lineages are PES1, CARD10, and TRIOBP. Each is linked with H3Y2 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3Y2-to-partner and partner-to-H3Y2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H3Y2 versus PES1 in PDAC, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3Y2→partner) and Y-score (partner→H3Y2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PES1 →	-0.308	-0.883	<.001	.007	3	1
PDAC	CARD10 →	-0.863	-1.515	<.001	.001	3	1
PDAC	TRIOBP →	-0.417	-1.058	.004	.003	3	1
PDAC	CCNB1IP1 →	-0.429	-1.071	.001	.001	3	1
PDAC	PYGB →	-0.990	-1.173	.001	.001	3	1
PDAC	UQCC1 →	-0.343	-1.228	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 858 associations by consensus.

H3Y2 vs PES1 — PDAC

Explore this scatter interactively →