H3Y1

Across TCGA pan-cancer cohorts, H3Y1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of H3Y1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where H3Y1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3Y1 is over-expressed in tumor.

BRCA and THCA are the cancer types where H3Y1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3Y1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	+0.303	<.001	4	view →
THCA	All	III,IV	+0.045	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

H3Y1–BRCA

Open the BRCA breakdown →