Across TCGA pan-cancer cohorts, H3P9 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of H3P9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H3P9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3P9 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, BRCA, and LUSC are the cancer types where H3P9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3P9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.074	.016	5	view →
BRCA	All	III,IV	−0.189	<.001	4	view →
LUSC	All	All	+0.134	.002	3	view →
LIHC	All	All	+0.155	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: H3P9 RNA expression & survival · all H3P9 data types