H3P39

Across TCGA pan-cancer cohorts, H3P39 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of H3P39’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where H3P39 RNA is repressed in tumor relative to normal tissue. In most cancer types H3P39 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

UCEC, BRCA, and LIHC are the cancer types where H3P39 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3P39 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	IV	−0.755	.002	6	view →
BRCA	All	III,IV	+0.249	<.001	6	view →
LIHC	Male	All	+0.160	.004	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

H3P39–UCEC

Open the UCEC breakdown →