H3P38

Across TCGA pan-cancer cohorts, H3P38 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated H3P38 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher H3P38 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H3P38 expression acts as an unfavorable survival marker, although some lineages such as HNSC and STAD show a favorable association.

BLCA, SKCM, and DLBC are the cancer types where H3P38 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.196	0.619	<.001	63	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	45	view →
DLBC	DFS	Tertile	IV	0.120	0.683	.001	36	view →
KIRP	OS	Tertile	II,III,IV	0.111	0.769	<.001	36	view →
LUSC	DFS	Tertile	III,IV	0.155	0.780	.010	36	view →
GBM	OS	Quartile	All	0.299	0.441	.003	21	view →
MESO	OS	Tertile	IV	0.036	0.602	<.001	18	view →
LIHC	OS	Tertile	All	0.403	0.790	.001	18	view →
LGG	OS	Tertile	All	0.745	0.897	.020	12	view →
HNSC	DFS	Tertile	All	0.853	0.624	.028	12	view →
THCA	DFS	Tertile	IV	0.456	0.825	.049	9	view →
READ	OS	Tertile	All	0.797	0.922	.043	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

H3P38–BLCA (OS)

Open the BLCA breakdown →