H3P35

Across TCGA pan-cancer cohorts, H3P35 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated H3P35 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher H3P35 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H3P35 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

STAD, KIRP, and COAD are the cancer types where H3P35 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	III,IV	0.398	0.665	.001	126	view →
KIRP	OS	Tertile	II,III,IV	0.111	0.769	<.001	81	view →
COAD	OS	Tertile	All	0.590	0.879	.001	66	view →
BLCA	DFS	Tertile	All	0.218	0.531	<.001	54	view →
HNSC	OS	Tertile	II,III,IV	0.086	0.711	<.001	54	view →
ACC	OS	Tertile	All	0.188	0.820	<.001	45	view →
LGG	DFS	Tertile	All	0.223	0.742	<.001	45	view →
KIRC	DFS	Tertile	III,IV	0.156	0.480	.008	36	view →
BRCA	DFS	Tertile	All	0.140	1.000	.001	36	view →
SKCM	DFS	Tertile	All	0.330	0.617	.025	18	view →
LIHC	DFS	Tertile	II,III,IV	0.093	0.429	.007	18	view →
SARC	DFS	Tertile	All	0.242	0.596	.036	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

H3P35–STAD (OS)

Open the STAD breakdown →