H3P3

Across TCGA pan-cancer cohorts, H3P3 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated H3P3 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher H3P3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated H3P3 expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

LUSC, THCA, and LIHC are the cancer types where H3P3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.923	0.656	.001	75	view →
THCA	DFS	Tertile	II,III,IV	0.179	0.749	.001	42	view →
LIHC	DFS	Tertile	All	0.161	0.556	.012	42	view →
SKCM	OS	Tertile	III,IV	0.180	0.707	<.001	36	view →
BLCA	OS	Tertile	IV	0.172	0.613	<.001	30	view →
CHOL	OS	Tertile	All	0.089	0.727	.001	27	view →
KIRC	OS	Tertile	II,III,IV	0.380	0.555	.023	18	view →
TGCT	OS	Tertile	All	0.869	0.968	.048	18	view →
STAD	DFS	Tertile	II,III,IV	0.551	0.753	.016	12	view →
BRCA	DFS	Tertile	IV	0.824	0.232	.025	12	view →
LUAD	OS	Tertile	All	0.705	0.334	.018	9	view →
OV	OS	Tertile	II,III,IV	0.448	0.308	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

H3P3–LUSC (OS)

Open the LUSC breakdown →