Across TCGA pan-cancer cohorts, H3P28 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of H3P28’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where H3P28 RNA is repressed in tumor relative to normal tissue. In most cancer types H3P28 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC and LUAD are the cancer types where H3P28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3P28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.053	.003	3	view →
LUAD	All	All	+0.042	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: H3P28 RNA expression & survival · all H3P28 data types