Q-omics provides the consensus-scored H3P27 profile across patient tissues and cancer cell-line models. H3P27 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in LIHC. Additionally, H3P27 RNA expression shows 6,144 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight LIHC, and STAD as cancer lineages where H3P27 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Premium analyses for H3P27 — synthetic lethality, tumor antigen, and pembrolizumab response.

View premium →

Survival associations

This table summarizes H3P27 survival associations across molecular data types. H3P27 RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

H3P27 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	14	LIHC (108)	view →

This table ranks reproducible H3P27 RNA expression–survival associations across cancer types. High H3P27 expression shows unfavorable associations in LIHC, ESCA, GBM, MESO and STAD, but favorable associations in OV. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for H3P27 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.130	0.712	<.001	108	view →
ESCA	OS	Tertile	All	0.522	0.944	.005	54	view →
OV	OS	Tertile	III,IV	0.810	0.659	.015	48	view →
GBM	DFS	Tertile	All	0.102	0.257	.001	36	view →
MESO	OS	Tertile	II,III,IV	0.130	0.571	.020	36	view →
STAD	DFS	Quartile	All	0.520	0.753	.001	34	view →

Pink = unfavorable, green = favorable. all 14 lineages →

H3P27-LIHC (OS)

Kaplan–Meier survival curve for H3P27 RNA expression in LIHC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with H3P27 in patient tissues and cancer cell lines. In patient samples, H3P27 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	6,144	STAD (5946)	view →
Protein (mass-spec)	3,591	GBM (1808)	view →