H3P25

Across TCGA pan-cancer cohorts, H3P25 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated H3P25 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher H3P25 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3P25 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

MESO, KIRP, and BLCA are the cancer types where H3P25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Quartile	All	0.215	0.459	<.001	105	view →
KIRP	DFS	Median	All	0.787	0.919	<.001	97	view →
BLCA	DFS	Tertile	IV	0.276	0.133	.013	43	view →
ACC	DFS	Tertile	III,IV	0.193	0.593	.001	35	view →
BRCA	DFS	Tertile	All	0.968	0.924	.004	29	view →
CESC	DFS	Tertile	All	0.770	0.883	.006	28	view →
LUAD	DFS	Median	IV	0.306	0.764	.010	19	view →
STAD	DFS	Quartile	III,IV	0.185	0.523	.013	14	view →
LGG	DFS	Quartile	All	0.273	0.520	<.001	14	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	12	view →
SKCM	OS	Median	II,III,IV	0.471	0.294	.011	10	view →
KIRC	DFS	Median	III,IV	0.380	0.534	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

H3P25–MESO (DFS)

Open the MESO breakdown →