H3P23

Across TCGA pan-cancer cohorts, H3P23 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of H3P23’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where H3P23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3P23 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

LIHC, LUAD, and BRCA are the cancer types where H3P23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3P23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	All	+0.050	.004	5	view →
LUAD	Female	All	+0.239	<.001	4	view →
BRCA	Female	II,III,IV	+0.142	<.001	4	view →
KIRP	Male	All	+0.126	.001	4	view →
KIRC	All	II,III,IV	−0.059	.025	3	view →
COAD	Male	IV	+0.288	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

H3P23–LIHC

Open the LIHC breakdown →