H3P16

Across TCGA pan-cancer cohorts, H3P16 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated H3P16 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher H3P16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3P16 expression acts as an unfavorable survival marker, although some lineages such as CESC and COAD show a favorable association.

ACC, KICH, and CESC are the cancer types where H3P16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.313	0.748	<.001	91	view →
KICH	DFS	Median	II,III,IV	0.650	1.000	<.001	86	view →
CESC	OS	Tertile	All	0.908	0.657	<.001	72	view →
UVM	DFS	Quartile	All	0.450	1.000	.003	47	view →
COAD	DFS	Tertile	IV	0.724	0.378	.006	38	view →
LUSC	OS	Tertile	All	0.744	0.555	<.001	33	view →
LIHC	DFS	Median	All	0.462	0.639	<.001	33	view →
KIRC	DFS	Quartile	II,III,IV	0.675	0.399	.013	19	view →
LGG	OS	Median	All	0.867	0.945	.005	18	view →
LAML	DFS	Tertile	All	0.425	0.657	.028	18	view →
OV	DFS	Quartile	IV	0.671	0.277	.001	14	view →
GBM	DFS	Quartile	All	0.429	0.195	.029	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

H3P16–ACC (DFS)

Open the ACC breakdown →