H3C6

Across TCGA patient cohorts, H3C6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3C6-associated genes across cancer lineages are Ku80, 14-3-3_epsilon, and PDCD4. Each is linked with H3C6 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C6-to-partner and partner-to-H3C6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by H3C6-low versus H3C6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C6→partner) and Y-score (partner→H3C6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.278	+3.335	.024	.005	3	1
UCEC	14-3-3_epsilon →	+0.113	+2.833	.029	.034	3	1
UCEC	PDCD4 →	-0.825	-3.321	<.001	.010	3	1
UCEC	SF2 →	+0.158	+2.183	.006	.035	3	1
UCEC	Src_pY527 →	-0.576	-3.169	.010	.018	3	1
UCEC	ATM →	-0.785	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by H3C6 expression — UCEC

Explore this box plot interactively →