H3C6

Across TCGA cell cohorts, H3C6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,563 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3C6-associated GO terms across cancer lineages are Autophagy, Endoplasmic reticulum to cytosol transport, and Retrograde protein transport, ER to cytosol. Each is linked with H3C6 in more than 9 cancer types. Because this analysis shows association rather than direction, both H3C6-to-partner and partner-to-H3C6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Autophagy grouped by H3C6-low versus H3C6-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C6→partner) and Y-score (partner→H3C6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Autophagy →	+0.058	+1.123	.009	.003	3	10
OVARY	Endoplasmic reticulum to cytosol transport →	+0.111	+1.425	<.001	<.001	3	10
OVARY	Retrograde protein transport, ER to cytosol →	+0.111	+1.425	<.001	<.001	3	10
OVARY	Protein exit from endoplasmic reticulum →	+0.096	+1.246	<.001	<.001	3	10
KIDNEY	Process utilizing autophagic mechanism →	+0.058	+1.123	.009	.003	3	10
LUNG_NSCLC_LUAD	Response to unfolded protein →	+0.073	+0.811	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,563 associations by consensus.

Autophagy by H3C6 expression — KIDNEY

Explore this box plot interactively →