H3C6

Across TCGA cell cohorts, H3C6 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H3C6-associated genes across cancer lineages are PRAMEF4, MT4, and MSGN1. Each is linked with H3C6 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C6-to-partner and partner-to-H3C6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF4 grouped by H3C6-low versus H3C6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C6→partner) and Y-score (partner→H3C6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRAMEF4 →	+0.084	+4.867	.006	.009	3	1
LARGE_INTESTINE	MT4 →	+3.892	+3.556	<.001	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1
LARGE_INTESTINE	S100G →	+1.372	+3.688	<.001	.002	3	1
LARGE_INTESTINE	UTF1 →	+0.018	+3.632	<.001	.003	3	1
LARGE_INTESTINE	TFDP3 →	+0.022	+4.518	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PRAMEF4 by H3C6 expression — BLOOD_Lymphoma

Explore this box plot interactively →