Across TCGA patient cohorts, H3C4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,097 significant associations in total. THYM shows the largest number of these associations.

The most reproducible H3C4-associated GO terms across cancer lineages are Protein localization to CENP-A containing chromatin, Organ or tissue specific immune response, and Innate immune response in mucosa. Each is linked with H3C4 in more than 32 cancer types. Because this analysis shows association rather than direction, both H3C4-to-partner and partner-to-H3C4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C4→partner) and Y-score (partner→H3C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Protein localization to CENP-A containing chromatin →	+1.224	+1.682	<.001	<.001	3	33
SCLC	Organ or tissue specific immune response →	+0.135	+1.085	.008	.003	1	26
TGCT	Innate immune response in mucosa →	+0.121	+1.852	<.001	<.001	3	24
ACC	Protein localization to chromosome, centromeric region →	+0.047	+1.158	<.001	<.001	3	21
SCLC	Protein localization to chromatin →	+0.104	+1.011	.003	.003	1	22
TGCT	Negative regulation of megakaryocyte differentiation →	+0.064	+1.483	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,097 associations by consensus.

Exploration

H3C4 survival (RNA) · tumor vs normal (RNA) · all H3C4 data types