H3C3

Across TCGA cell cohorts, H3C3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,827 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3C3-associated GO terms across cancer lineages are Positive regulation of circadian rhythm, Regulation of centromeric sister chromatid cohesion, and Post-embryonic eye morphogenesis. Each is linked with H3C3 in more than 4 cancer types. Because this analysis shows association rather than direction, both H3C3-to-partner and partner-to-H3C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of circadian rhythm grouped by H3C3-low versus H3C3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C3→partner) and Y-score (partner→H3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of circadian rhythm →	+0.156	+1.083	.004	.001	3	5
LIVER	Regulation of centromeric sister chromatid cohesion →	+0.147	+1.171	<.001	.003	3	5
SOFT_TISSUE	Post-embryonic eye morphogenesis →	+0.728	+0.618	<.001	.001	3	5
BONE	Innate immune response in mucosa →	-0.139	-0.755	<.001	<.001	3	5
STOMACH	Vacuolar transmembrane transport →	+0.173	+0.849	.008	.003	3	4
LARGE_INTESTINE	Regulation of protection from non-homologous end joining at telomere →	+0.083	+0.416	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,827 associations by consensus.

Positive regulation of circadian rhythm by H3C3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →