H3C3

Across TCGA cell cohorts, H3C3 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3C3-associated genes across cancer lineages are H2BC1, H2AC1, and KRTAP21-2. Each is linked with H3C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C3-to-partner and partner-to-H3C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by H3C3-low versus H3C3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C3→partner) and Y-score (partner→H3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRTAP21-2 →	+0.313	+4.930	<.001	.008	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1
BLOOD_Leukemia	LGI1 →	+0.129	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

H2BC1 by H3C3 expression — SOFT_TISSUE

Explore this box plot interactively →