Across TCGA pan-cancer cohorts, H3C14 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of H3C14’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where H3C14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3C14 is over-expressed in tumor.
LUSC, KICH, and HNSC are the cancer types where H3C14 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3C14 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.