Across TCGA patient cohorts, H3C12 mutation is significantly associated with the RNA expression of many other genes, with 656 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3C12-associated genes across cancer lineages are RNA5SP369, MLLT10P2, and MIR8082. Each is linked with H3C12 in more than 2 cancer types. Because this analysis shows association rather than direction, both H3C12-to-partner and partner-to-H3C12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C12→partner) and Y-score (partner→H3C12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP369 →	+0.447	+5.539	<.001	.004	3	3
UCEC	MLLT10P2 →	+0.138	+2.541	<.001	.007	3	3
UCEC	MIR8082 →	+0.356	+2.687	<.001	.001	3	2
UCEC	YTHDF3-AS1 →	+0.819	+2.276	<.001	.005	3	1
UCEC	SNRPGP17 →	+0.215	+2.048	.009	.003	3	1
UCEC	RNU6-94P →	+0.638	+3.338	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 656 associations by consensus.

Exploration

H3C12 survival (RNA) · tumor vs normal (RNA) · all H3C12 data types